The Robert Wood Johnson Foundation (RWJF) is committed to seeking value from all levels of investment in health care, public health, and population health. Through this call for proposals the Foundation intends to pursue several objectives: (1) to identify promising innovations to improve health being implemented in low-resource communities, (2) to evaluate whether the innovations improve health care quality and health without increasing costs; and (3) to disseminate these innovations as examples for other communities to implement. The evaluation of innovations from low-resource communities is the primary objective of this call for proposals.